MOTS-c: A Mitochondrial Peptide Research Overview

MOTS-c is a mitochondrial-derived peptide that has attracted significant research interest in the study of metabolism and cellular ageing. It is encoded within mitochondrial DNA, which distinguishes it from most other research peptides.

What is MOTS-c?

MOTS-c (“mitochondrial open reading frame of the twelve S rRNA-c”) is a short peptide expressed from the mitochondrial genome. In research it is studied as a signalling molecule linking mitochondrial function to whole-cell metabolism.

Pathways studied in the literature

• AMPK signalling and cellular energy regulation.
• Glucose and lipid metabolism in animal models.
• Mitochondrial stress responses and metabolic homeostasis.
• Exercise-mimetic and ageing-related endpoints.

Summary of research findings

MOTS-c research largely comprises in vitro and animal studies examining metabolic and mitochondrial endpoints. It is studied as a tool for understanding mitochondrial-to-nuclear signalling. Translation of these findings is an active area of investigation.

The research described here refers to laboratory and preclinical studies. Defined Labs products are supplied strictly for in vitro research use only.